Question 1

In humans, pyruvate can be converted to

Accepted Answer

A)   acetyl-CoA only.
B)   lactate only.
C)   ethanol only.
D)   acetyl-CoA and lactate.E) A) and B)
F) A) and C)

Question 2

​ Phosphorylation of fructose 6-phosphate to produce fructose-1,6- bis phosphate happens in the _____ step of glycolysis.

Accepted Answer

A)   first
B)   second
C)   third
D)   fourthE) A) and D)
F) A) and C)

Question 3

Which of the following enzymes forms a thioester using a cysteine residue as a key intermediate?

Accepted Answer

A)   hexokinase
B)   triose phosphate isomerase
C)   glyceraldehyde-3-phosphate dehydrogenase
D)   enolaseE) A) and C)
F) C) and D)

Question 4

Enolase catalyzes

Accepted Answer

A)   the cleavage of fructose bis phosphate into two 3-carbon units.
B)   the dehydration of 2-phosphoglycerate.
C)   the conversion of phosphoenolpyruvate to pyruvate.
D)   the conversion of glucose-6-phosphate to fructose-6-phosphate.E) All of the above
F) C) and D)

Question 5

During glycolysis, enolase , the enzyme that catalyzes the conversion of 2-phophoglycerate to phosphoenolpyruvate requires _____ as a cofactor.

Accepted Answer

A)   Fe2+
B)   Cu2+
C)   Mg2+
D)   Zn2+E) B) and C)
F) A) and D)

Question 6

Which of the following terms describes an enzyme that transfers a phosphate group from ATP to a substrate?

Accepted Answer

A)   kinase
B)   isomerase
C)   mutase
D)   dehydrogenaseE) A) and B)
F) A) and C)

Question 7

During glycolysis, ATP is synthesized from ADP and a phosphate group transferred from an acid anhydride.

Accepted Answer

A) True 
 B)False

Question 8

What is the relationship between glycolysis and cancer?

Accepted Answer

A)   cancer cells lack a glycolytic pathway
B)   cancer cells use a modified version of glycolysis
C)   cancer cells exhibit a much higher level of anaerobic glycolysis than normal cells
D)   none of theseE) A) and B)
F) A) and D)

Question 9

The fate of pyruvate produced during glycolysis depends primarily on the availability of

Accepted Answer

A)   NAD+ to keep the pathway going.
B)   molecular oxygen.
C)   ADP for conversion to ATP.
D)   coenzyme A for further metabolism of pyruvate.
E)   phosphoric acid for the synthesis of ATP.F) B) and D)
G) B) and E)

Question 10

Which of the following glycolytic enzymes forms a mixed anhydride from phosphoric acid?

Accepted Answer

A)   hexokinase.
B)   phosphofructokinase.
C)   glyceraldehyde-3-phosphate dehydrogenase.
D)   phosphoglycerate kinase.
E)   pyruvate kinase.F) A) and D)
G) A) and C)

Question 11

Consider the following information:  How many molecules of ATP might theoretically have been produced when coupled to the conversion of one molecule phosphoenolpyruvate to pyruvate?

Accepted Answer

A)   1
B)   2
C)   3
D)   4E) B) and C)
F) C) and D)

Question 12

How many enzymes of glycolysis are control points for the pathway?

Accepted Answer

A)   1
B)   2
C)   3
D)   4
E)   All the enzymes serve as control points.F) B) and E)
G) B) and C)

Question 13

The binding of glucose to hexokinase

Accepted Answer

A)   is an example of lock-and-key binding of a substrate to the active site of an enzyme.
B)   is an example of induced-fit binding of a substrate to the active site of an enzyme.
C)   differs from the binding of substrates to other kinases.
D)   is not well characterized.E) None of the above
F) A) and D)

Question 14

An enzyme not involved in the control of glycolysis is

Accepted Answer

A)   hexokinase.
B)   triose phosphate isomerase.
C)   pyruvate kinase.
D)   phosphofructokinase.E) B) and D)
F) All of the above

Question 15

Which of the following is required for substrate-level phosphorylation?

Accepted Answer

A)   The substrate must contain multiple phosphate groups.
B)   Molecular oxygen must present.
C)   The standard free energy of the hydrolysis reaction is more negative than that for hydrolysis of the new phosphate compound being formed.
D)   All of the above are necessary for substrate-level phosphorylation.E) None of the above
F) A) and B)

Question 16

The phosphorylation of glucose to glucose 6-phosphate

Accepted Answer

A)   is so strongly exergonic that it does not require a catalyst.
B)   is an exergonic reaction not coupled to any other reaction.
C)   is an endergonic reaction that takes place because it is coupled to the exergonic hydrolysis of ATP.
D)   is an exergonic reaction that is coupled to the endergonic hydrolysis of ATP.E) A) and D)
F) C) and D)

Question 17

The equilibrium for isomerization of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate is favored because

Accepted Answer

A)   the standard free energy is negative
B)   glyceraldehyde-3-phosphate is being continuously drained off for the subsequent reaction in the glycolytic pathway
C)   the value of the equilibrium constant favors the reaction
D)   it is driven by the hydrolysis of ATPE) B) and D)
F) A) and B)

Question 18

Methanol is extremely toxic, but not directly. In the body, it is converted into formaldehyde; that's what's actually the poison. What kind of enzyme catalyses this conversion?

Accepted Answer

A)   a kinase
B)   an isomerase
C)   a mutase
D)   a dehydrogenaseE) A) and B)
F) A) and C)

Question 19

Anaerobic metabolism can occur in all these organisms or cells, except :

Accepted Answer

A)   Yeast
B)   Red blood cells
C)   Muscle tissue that is working very fast
D)   Lactobacillus in milk
E)   Anaerobic metabolism can occur in all of these.F) A) and B)
G) A) and E)

Question 20

Glycolysis

Accepted Answer

A)   does not require O2 to generate energy.
B)   requires O2 to generate energy.
C)   is inhibited by O2.
D)   rate is increased in the presence of O2.E) A) and B)
F) A) and C)

Exam 17: Glycolysis

Consider the following information: How many molecules of ATP might theoretically have been produced when coupled to the conversion of one molecule phosphoenolpyruvate to pyruvate?

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Which of the following enzymes forms a thioester using a cysteine residue as a key intermediate?

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In humans, pyruvate can be converted to

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Anaerobic metabolism can occur in all these organisms or cells, except :

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What is the relationship between glycolysis and cancer?

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Enolase catalyzes

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An enzyme not involved in the control of glycolysis is

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The binding of glucose to hexokinase

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During glycolysis, ATP is synthesized from ADP and a phosphate group transferred from an acid anhydride.

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Glycolysis

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During glycolysis, enolase , the enzyme that catalyzes the conversion of 2-phophoglycerate to phosphoenolpyruvate requires _____ as a cofactor.

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Which of the following glycolytic enzymes forms a mixed anhydride from phosphoric acid?

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Methanol is extremely toxic, but not directly. In the body, it is converted into formaldehyde; that's what's actually the poison. What kind of enzyme catalyses this conversion?

Correct AnswerverifiedShow Answer

​ Phosphorylation of fructose 6-phosphate to produce fructose-1,6- bis phosphate happens in the _____ step of glycolysis.

Correct AnswerverifiedShow Answer

The equilibrium for isomerization of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate is favored because

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How many enzymes of glycolysis are control points for the pathway?

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Which of the following terms describes an enzyme that transfers a phosphate group from ATP to a substrate?

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The fate of pyruvate produced during glycolysis depends primarily on the availability of

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Which of the following is required for substrate-level phosphorylation?

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The phosphorylation of glucose to glucose 6-phosphate

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Phosphorylation of fructose 6-phosphate to produce fructose-1,6- bis phosphate happens in the _____ step of glycolysis.

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